|
The goal of downstream process (DSP) development for bispecific antibodies (BsAbs) is to develop a method for obtaining highly purified bsAbs with optimal recovery and quality. Like traditional antibodies, the concept of the chromatography platform can be applied to DSP development. However, bsAb DSP development is more challenging due to the higher complexity of product-related impurities. The principle of the bsAb purification strategy was mainly based on the difference between the product and the impurities, as illustrated in Figure 1. In addition, some additives could be used to improve resolution during chromatography. |
||||
|
|
|
The goal of downstream process (DSP) development for bispecific antibodies (BsAbs) is to develop a method for obtaining highly purified bsAbs with optimal recovery and quality. Like traditional antibodies, the concept of the chromatography platform can be applied to DSP development. However, bsAb DSP development is more challenging due to the higher complexity of product-related impurities. The principle of the bsAb purification strategy was mainly based on the difference between the product and the impurities, as illustrated in Figure 1. In addition, some additives could be used to improve resolution during chromatography. |
||||
|
|
